The use of recombinant proteins to treat many diseases has been considered by biotechnology researchers, so that today we see the use of recombinant pharmaceutical products, instead of the previous chemical drugs. These proteins have a specific function and because they originate from the body's biological molecules. Many prokaryotic and eukaryotic cells are used as hosts for the production of these proteins, advantages to using a system that best preserves the properties of natural protein, and should be able to maintain high production, high purification, short time, maximum protein biological activity. Lucelia sericata larvae degrade dead wound tissue, produce neurogenesis, and subsequently wound healing by producing a variety of wound-degrading enzymes and proteins. Larval secretions include a variety of proteolytic enzymes(leucine, carboxypeptidase, aminopeptidases, collagenases,…) , growth factors, antimicrobial peptides, anti-inflammatory and other unknown compounds in wound healing. Due to the development of biological science and the production of recombinant proteins, miraculous peptide materials of larval secretions can be produced as recombinant proteins. And replaced them with chemical drugs and antibiotics to treat wounds.