In skin and organic tissues; injuries caused by many factors such as chemical, electrical, friction, flame, and radioactivity are called burns. Burn injury causes serious mortality and morbidity. In addition, hospitalization period and rehabilitation period is one of the longest traumas. Lipolysis, proteolysis, glycolysis and high fever and hyperdynamic and hypermetabolic responses are seen in burn patients who are affected in more than 20% of total body surface area. These hypermetabolic responses in patients lead to a decrease in lean muscle mass, delay in wound healing, weakening of the immune system and serious mortality. In the first 24 hours after the major burns, fluid accumulation is seen in the interstitial space due to increased vascular permeability. The reduced intravascular volume affects tissue perfusion if not interfered. Cardiac output decreases, all systems including the gastrointestinal system and renal system are affected. Depending on the burn, the electrolytes in the body are also affected and as a result of this effect cell death may occur.